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凋亡抑制家族成员survivin具有细胞凋亡抑制、调节细胞周期及参与血管生成功能,与多数恶性肿瘤发生发展关系密切。研究表明survivin表达与子宫内膜癌组织学分级、临床分期及肌层浸润深度相关,认为其在子宫内膜癌发生、发展中起重要作用,可能为子宫内膜癌诊断与预后提供重要依据,但亦有研究认为其可能是子宫内膜癌发生的早期事件,与癌症进展无相关性。多数相关研究均提示,survivin在正常成人组织中不表达或弱表达,而在恶性肿瘤中则过表达,该特点使其成为肿瘤治疗研究的重要靶标,目前survivin在子宫内膜癌治疗研究亦逐渐展开,可能为今后子宫内膜癌诊断、治疗、预后研究开辟新途径。
Survivin, a member of apoptosis-inhibiting family, has the functions of inhibiting apoptosis, regulating cell cycle and participating in angiogenesis, which is closely related to the occurrence and development of most malignant tumors. Studies have shown that survivin expression and endometrial cancer histological grade, clinical stage and the depth of myometrial invasion, that it plays an important role in the occurrence and development of endometrial cancer, which may provide an important basis for the diagnosis and prognosis of endometrial cancer, However, some studies suggest that it may be an early event of endometrial cancer, and no correlation with the progress of cancer. Most studies suggest that survivin is not expressed or weakly expressed in normal adult tissues but overexpressed in malignant tumors, which makes it an important target for cancer therapy research. At present, survivin is gradually being studied in the treatment of endometrial cancer Expand, may open up new avenues for the future diagnosis, treatment and prognosis of endometrial cancer.