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目的建立超高效液相色谱-串联四极杆飞行时间质谱法测定男性外用壮阳喷剂中非法添加盐酸丁卡因的检测方法。方法样品采用C_(18)色谱柱分离,以0.05%甲酸水溶液和乙腈梯度洗脱,采用飞行时间质谱(TOF)和选择离子监测(Target MS/MS)模式检测。结果经对照品确认,样品中检测出盐酸丁卡因。结论本方法可以用于快速鉴定男性外用壮阳类喷剂中非法添加盐酸丁卡因的检测。
Objective To establish a method for the determination of tetracaine hydrochloride in male external aphrodisiac sprays by ultra performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry. Methods The samples were separated on a C_ (18) column and eluted with 0.05% formic acid in water and acetonitrile gradient. The samples were detected by TOF and Target MS / MS. Results confirmed by the reference substance, detected in the sample of tetracaine hydrochloride. Conclusion This method can be used to quickly identify male external aphrodisiac spray illegally added tetracaine hydrochloride detection.