最近,美国FDA批准采用一种放射免疫分析方法测定环孢菌素(Cyclosporine)的浓度。由于放射免疫分析与高效液相色谱分析方法的专一性不同,因此两者不可交替使用。由于用于放射免疫分析的抗体与几种环孢菌素代谢物产生交叉反应,所以由治疗范围所确定的两种分析技术不可交替使用。 (周仁全摘) Recently, the U.S. FDA approved the use of a radioimmunoassay to determine the concentration of cyclosporine. Due to the different specificity of radioimmunoassay and HPLC methods, the two can not be used interchangeably. Since the antibodies used for radioimmunoassay cross-react with several cyclosporin metabolites, the two analytical techniques defined by the therapeutic range can not be used interchangeably. (Zhouren all picks)