为了寻找新型高效低毒的抗真菌药，根据氮唑类抗真菌药物的构效关系和作用机理，设计合成了８个２（取代苯氧基）甲基４（２，４二氟苯基）４（１Ｈ１，２，４三唑１基）甲基１，３二氧戊环类化合物。初步的体外抗真菌活性试验表明，所有的目标化合物对５种常见的深部致病真菌都有不同程度的抗真菌活性，所有目标化合物的活性与克霉唑相当或更高，特别是对白念珠菌、新生隐球菌、卡氏枝孢菌效果尤其显著 In order to find new antifungal agents with high toxicity and low toxicity, eight 2-substituted phenoxymethyl-4 (2,4-difluoro Phenyl)  4  (1H  1, 2,4  triazole  1  base) methyl  1, 3  dioxolane compounds. Preliminary in vitro antifungal activity tests showed that all of the target compounds had varying degrees of antifungal activity against five common deep pathogenic fungi and that all of the target compounds were comparable or higher in activity to clotrimazole, , Cryptococcus neoformans, Cladosporium card particularly effective