胰岛素病是由于胰岛素原先天性分子结构异常,或转变为胰岛素的机制发生障碍以致患者血浆胰岛素原样物质(proinsulin-like material, PLM)水平增高,又称为家族性高胰岛素原血症(FM),部分患者呈非胰岛素依赖型糖尿病.其次,胰岛素分子结构异常或受体结合处的缺陷因而半衰期延长,效应降低,出现高胰岛素血症.兹将近年研究进展综述如下. Insulin disease is due to the structural abnormalities of the original proinsulin of insulin, or the mechanism of conversion to insulin, which leads to the increase of the level of plasma proinsulin-like material (PLM), also known as familial hyperinsulinism (FM) Some patients were non-insulin-dependent diabetes mellitus.Secondly, insulin structural abnormalities or receptor defects at the junction and thus prolonged half-life, the effect is reduced, hyperinsulinism appears.