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目的研究来曲唑微刺激促排卵应用于卵巢储备降低患者行IVF-ET的效果。方法 346名拟行IVF-ET的卵巢储备降低的不孕患者随机分成来曲唑微刺激促排卵组(A组n=226)和GnRH-a短方案组(B组n=120),比较两组促排卵天数,Gn总量,获卵数,优胚率、临床妊娠率,多胎率和流产率。结果来曲唑促排组促排天数、Gn总量、诱导日E2、获卵数、受精率、可利用胚胎数、种植率、临床妊娠率显著低于短方案组(P<0.05),诱导日LH、P水平高于Gn-RHa短方案组(P<0.05),而两组的诱导日内膜厚度、卵裂率、优质胚胎率、移植胚胎数、多胎率、流产率差异均无显著统计学意义(P>0.05)。结论对于卵巢储备降低的患者行IVF-ET助孕时来曲唑微刺激促排卵可以减少Gn用量,但是在妊娠率上并不优于GnRH-a短方案。
Objective To investigate the effect of letrozole micro stimulating ovulation on ovarian reserve to reduce IVF-ET in patients. Methods A total of 346 infertile women with reduced ovarian reserve for IVF-ET were randomly divided into two groups: noradrenaline stimulation group (n = 226) and GnRH-a short protocol group (n = 120) Days of ovulation induction, Gn total number of oocytes, excellent embryo rate, clinical pregnancy rate, multiple birth rate and abortion rate. The results showed that letrozole was able to promote the number of days, the total amount of Gn, the induction day E2, the number of oocytes retrieved, the fertilization rate, the number of available embryos, the implantation rate and the clinical pregnancy rate were significantly lower than those in the short-term group (P <0.05) Day LH and P levels were higher than Gn-RHa short-term group (P <0.05). There was no significant difference in intima thickness, cleavage rate, high-quality embryo rate, embryo transfer number, multiple birth rate and abortion rate Statistical significance (P> 0.05). Conclusions Levofloxacin can decrease Gn dosage in IVF-ET assisted pregnancy in patients with decreased ovarian reserve, but pregnancy rate is not superior to GnRH-a short protocol.