以亚甲二氧基苯为起始原料,经过溴化、硫化、环化等反应合成了19个未见文献报道的6,7-亚甲二氧基硫代苯并二氢吡喃-4-酮衍生物,其结构均经核磁共振氢谱和质谱确认。初步抑菌活性测试结果表明,在50 mg/L下,目标化合物对供试7种植物病原菌均有不同程度的抑制作用,其中化合物5b、5i、5k和5l对马铃薯干腐病菌Fusarium solani的抑制率均达75%以上,5h和5i对番茄灰霉病菌Botrytis cinerea的抑制率分别是67.7%和70.4%。 19 methylenedioxythiochroman-4 (6,7-methylenedioxythiochroman-4-one) were synthesized by the reaction of bromination, sulfurization and cyclization with methylenedioxybenzene as the starting material. - ketone derivatives, the structures were confirmed by 1H nuclear magnetic resonance and mass spectrometry. The results of the preliminary antibacterial activity test showed that the target compounds inhibited the seven plant pathogenic fungi to varying degrees at 50 mg / L, of which compounds 5b, 5i, 5k and 5l inhibited the growth of Fusarium solani The rates of 5h and 5i on Botrytis cinerea were 67.7% and 70.4%, respectively.