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目的：探讨采用自体外周血干细胞移植（简称ＡＳＣＴ）治疗老年多发性骨髓瘤（简称ＭＭ）疗效及安全性。方法：采用大剂量马法兰联合阿糖胞苷和环磷酰胺作预处理，大剂量阿糖胞苷结合Ｇ－ＣＳＦ作动员剂。结果：２例患者均顺利渡过危险期。主要副作用是骨髓抑制、胃肠道反应及口腔溃疡等。生存期分别为２４月和１２月，移植后缓解时间分别为１６月和５月。结论：ＡＳＣＴ采用ＭＡＣ方案作预处理疗效好、安全性高，其不良反应是可耐受的
Objective: To investigate the efficacy and safety of autologous peripheral blood stem cell transplantation (ASCT) in the treatment of elderly multiple myeloma (MM). METHODS: Large doses of melphalan combined with cytarabine and cyclophosphamide were used for pretreatment, and high doses of cytarabine combined with G-CSF as mobilizer. Results: Both patients successfully passed the dangerous period. The main side effects are myelosuppression, gastrointestinal reactions, and oral ulcers. The survival periods were 24 months and 12 months respectively, and the post-transplantation relief times were 16 months and 5 months, respectively. Conclusion: The MAC treatment of ASCT has good curative effect and high safety, and its adverse reactions are tolerable.