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目的了解Graves病患者甲状腺激素水平对血糖、血脂及尿酸代谢状况的影响。方法对26例Graves病患者治疗前后的甲状腺激素(TH)水平、空腹血糖(FBG)和餐后血糖水平(PBG)、血脂水平、尿酸(UA)水平进行对照分析。结果 26例Graves病患者治疗前后对比,游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)明显降低,促甲状腺激素(hhTSH)明显升高,PBG水平明显降低,总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白(HDL-C)均明显升高,尿酸改变不明显。结论甲状腺激素水平对体内血糖及血脂代谢有显著影响。临床上在诊治Graves病时,应当加强血糖、血脂水平的监测,以便更好地指导临床诊治,为了解疾病的发生发展、提供有价值的实验室检测指标。
Objective To understand the effect of thyroid hormone on blood glucose, blood lipid and uric acid metabolism in patients with Graves’ disease. Methods Thyroid hormone (TH), fasting blood glucose (FBG) and postprandial blood glucose (PBG), blood lipid and uric acid (UA) levels were measured in 26 patients with Graves’ disease before and after treatment. Results Before and after treatment, the levels of free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (hhTSH), PBG level and total cholesterol (TC) , Triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein (HDL-C) were significantly increased, uric acid change was not obvious. Conclusions Thyroid hormone levels have a significant effect on blood glucose and lipid metabolism in vivo. Clinic diagnosis and treatment of Graves disease, blood glucose and blood lipid levels should be strengthened monitoring, in order to better guide the clinical diagnosis and treatment, in order to understand the occurrence of the disease, provide valuable laboratory test indicators.