头孢菌素类抗生素,因其具有广谱抗菌性质,所以是一类非常重要的化疗剂。但是近来对一些老的头孢菌素耐药的菌增多了,因此必须发展新的具有高效、广谱且对耐药菌有更高效力的抗菌素。近年来发展了一些新的头孢菌素衍生物,如氨噻肟头孢菌素和氧哌羟苯唑头孢菌素。这些新的头孢菌素具有较广的抗菌谱对β—内酰胺酶有更高的稳定 Cephalosporins antibiotics, because of its broad-spectrum antibacterial properties, it is a very important class of chemotherapeutic agents. However, some older cephalosporin-resistant bacteria have recently increased, and new antibiotics that are highly effective, broad-spectrum and more effective against resistant bacteria must be developed. In recent years, some new cephalosporin derivatives have been developed, such as cefotaxime and cefoperazone. These new cephalosporins have a broader antimicrobial spectrum of β-lactamase with higher stability