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构建小鼠人急性白血病模型的方法包括人白血病细胞异种移植、逆转录病毒转导/移植、小鼠转基因、化学诱变、插入诱变等。通过异种移植构建小鼠人急性白血病模型是当前研究急性白血病的重要手段之一。本文就免疫缺陷鼠、预处理及细胞因子、细胞接种、模型评估及模型应用方面,介绍异种移植构建小鼠人急性白血病模型的最新进展。
Methods to construct mouse acute leukemia models include human leukemia cell xenotransplantation, retroviral transduction / transplantation, mouse transgenic, chemical mutagenesis, insertional mutagenesis and the like. The construction of mouse acute leukemia model by xenotransplantation is one of the most important ways to study acute leukemia. In this paper, immunodeficiency mice, pretreatment and cytokines, cell inoculation, model evaluation and model application, introduces the latest progress of xenotransplantation to construct mouse acute leukemia model.