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本文分析了第三脑室注射组胺（HA）抑制胃酸分泌效应的外周过程。雄性SD大鼠，摘除双侧肾上腺，用37℃的生理盐水通过恒流泵进行连续胃灌流。用注射器泵静脉每小时给药，观察其对五肽促胃液素（10μg/kg，iv）诱导的胃酸分泌的影响。结果如下：（1）切除双侧膈下迷走神经可阻断HA（1μg，icv）的中枢抑酸效应；（2）预先静脉注射硫酸阿托品［0.05mg／（kg·100min）］可阻断HA的中枢抑酸效应；（3）预先静脉注射生长抑素拮抗剂[2～4μg/（kg·100min）]，可剂量依赖性地拮抗HA的中枢抑酸效应。结果提示：HA的中枢抑酸效应由迷走神经传出，可能通过乙酰胆碱M受体及引起生长抑素释放实现。
This article analyzes the third ventricle histamine (HA) inhibition of gastric acid secretion in the peripheral process. Male Sprague-Dawley rats, bilateral adrenal glands were excised, and continuous gastric perfusion was performed with a constant-current pump at 37 ° C. The mice were intravenously administered with a syringe pump every hour to observe the effects on gastric acid secretion induced by pentagastrin (10 μg / kg, iv). The results were as follows: (1) The removal of bilateral subdiaphragmatic vagus nerve blocked the central suppressive effect of HA (1μg, icv); (2) Pretreatment of intravenous injection of atropine sulfate [0.05mg / (kg · 100min) (3) Preinjection of somatostatin antagonist [2 ~ 4μg / (kg · 100min)] in a dose-dependent manner can antagonize the central inhibitory effect of HA in a dose-dependent manner. The results suggest that the central inhibitory effect of HA from the vagus nerve may be mediated by acetylcholine M receptor and the release of somatostatin.