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作者对35例高血压患者每天给予可乐宁盐酸盐(Clonidine HCI,一种咪唑啉类抗高血压药物)治疗,平均疗程14个月,最长达25个月。剂量从0.075～4.8毫克/日不等。大多数患者在接受可乐宁治疗7个月后,加用一种利尿剂(如氯噻酮或双氢氯噻嗪)。29例单用可乐宁治疗的患者中,有13例(45％)达到最大治疗反应(血压降至正常或平均动脉压下降20毫米汞柱以上);而33例用可乐宁加利尿剂治疗的患者中,有29例(88％)获得此种治疗反应。可乐宁的副作用主要有口干和嗜睡,这些在加用利尿剂时,大为
The authors treated 35 hypertensive patients daily with Clonidine HCI (an imidazoline antihypertensive drug) for an average of 14 months, up to 25 months. Dosages range from 0.075 to 4.8 mg / day. Most patients receive a diuretic (eg, chlorthalidone or hydrochlorothiazide) after 7 months of treatment with clonidine. Of the 29 patients treated with clonidine alone, 13 (45%) achieved the maximal response to treatment (blood pressure dropped to normal or mean arterial pressure dropped more than 20 mmHg); whereas 33 patients treated with clonidine plus diuretics Twenty-nine patients (88%) received this treatment response. The main side effects of clonidine dry mouth and drowsiness, these add diuretics, greatly