本文报道用液相法合成胆囊收缩素活性多肽带保护基的类似物。合成采用N端延长法,以苄氧羰基和叔丁氧羰基为保护基,活性酯法形成肽键。六个带保护基的寡肽均未见文献报道,其结构经氨基酸分析、旋光、红外光谱、质谱确证。经初步药理实验,它们都具有一定生物活性。 This paper reports the use of liquid phase synthesis of cholecystokinin active peptide analogs with a protective group. N-terminal extension of the synthesis method to benzyloxycarbonyl and tert-butoxycarbonyl as a protective group, the active ester method to form peptide bonds. Six oligopeptides with protective groups were not reported in the literature, the structure of amino acids, optical rotation, infrared spectroscopy, mass spectrometry confirmed. After preliminary pharmacological experiments, they all have certain biological activity.