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目的:探讨人骨桥蛋白(osteopontin,OPN)和细胞表面黏附分子CD44v6在卵巢癌中的表达情况及其与卵巢癌临床病理特征之间的关系,并分析OPN与CD44v6之间的相关性,进一步阐明OPN和CD44v6在卵巢癌侵袭和转移过程中的作用。方法:通过免疫组织化学(免疫组化)SP法检测骨桥蛋白和CD44v6在正常卵巢组织、卵巢良性、交界性、恶性肿瘤组织中的表达。结果:①OPN和CD44v6的阳性表达在卵巢交界性肿瘤、卵巢癌组与正常对照组和良性肿瘤之间差异有统计学意义(P<0.05),良性肿瘤组与正常组差异无统计学意义(P>0.05);②骨桥蛋白、CD44v6在卵巢癌中的表达与肿瘤的分化程度、肿瘤的临床分期及有无淋巴结转移有关,差异有统计学意义(P<0.05或P<0.01),而与上皮性肿瘤中的不同组织学类型无关,差异无统计学意义(P>0.05);③采用配对资料相关分析发现,OPN与CD44v6的表达之间有显著正相关性(r=0.753,P<0.05)。结论:OPN、CD44v6在卵巢上皮性癌中呈高表达,并与临床分期、分级、淋巴结转移有关,在卵巢癌组织中OPN的表达与CD44v6呈正相关,提示OPN与CD44v6的协同作用可能对卵巢癌进展起重要作用。
OBJECTIVE: To investigate the expression of osteopontin (OPN) and cell surface adhesion molecule CD44v6 in ovarian cancer and its relationship with the clinicopathological features of ovarian cancer. The correlation between OPN and CD44v6 was further elucidated Role of OPN and CD44v6 in Invasion and Metastasis of Ovarian Cancer. Methods: The expressions of osteopontin and CD44v6 in normal ovarian tissue, benign ovarian, borderline and malignant tumor tissues were detected by immunohistochemistry (SP method). Results: ① The positive expression of OPN and CD44v6 in borderline ovarian tumors, ovarian cancer group and normal control group and benign tumors were significantly different (P <0.05), there was no significant difference between benign tumor group and normal group (P > 0.05). ② The expression of osteopontin and CD44v6 in ovarian cancer was correlated with the degree of tumor differentiation, tumor stage and lymph node metastasis (P <0.05 or P <0.01) (P> 0.05) .③The paired data analysis showed that there was a significant positive correlation between the expression of OPN and CD44v6 (r = 0.753, P <0.05), but no significant difference was found between the different histological types of epithelial tumors ). Conclusion: The expression of OPN and CD44v6 in epithelial ovarian cancer is highly correlated with clinical stage, grade and lymph node metastasis. The expression of OPN in ovarian cancer is positively correlated with CD44v6, suggesting that the synergistic effect of OPN and CD44v6 may play an important role in ovarian cancer Progress plays an important role.