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目的探讨凝结芽孢杆菌活菌片(商品名:爽舒宝)治疗母乳性黄疸的临床疗效。方法将母乳性黄疸患儿69例随机分为观察组和对照组,观察组34例在常规治疗的同时给予口服凝结芽孢杆菌活菌片;对照组35例应用蓝光、茵栀黄颗粒等常规治疗。治疗中观察患儿黄疸消退时间并定期检测血清胆红素含量,血常规情况。结果治疗后观察组总有效率、日均胆红素下降值均明显高于对照组,治疗第5天血清胆红素值低于对照组,黄疸消退时间亦明显短于对照组,差异具有统计学意义(P<0.05)。观察组和对照组的白细胞计数和红细胞计数均降为正常值,血红蛋白也有所降低,但仍高于正常值,差异无统计学意义(P>0.05)。结论凝结芽孢杆菌活菌片治疗母乳性黄疸,可提高总有效率,迅速降低胆红素水平,缩短黄疸消退时间,且无不良反应发生。
Objective To investigate the clinical efficacy of Bacillus coagulans viable tablets (trade name Shuang Shu-Po) in the treatment of breast milk jaundice. Methods 69 cases of breast milk jaundice were randomly divided into observation group and control group. 34 cases in observation group were treated with oral Bacillus coagulans via routine treatment. 35 cases in control group were treated with routine therapy such as blue light and Yinzhihuang granules . Treatment of children with jaundice regression time and regular detection of serum bilirubin, blood conditions. Results After treatment, the total effective rate of the observation group, the daily average bilirubin decreased significantly higher than the control group, the 5th day of treatment serum bilirubin value was lower than the control group, jaundice subsided time was also significantly shorter than the control group, the difference was statistically Significance (P <0.05). The white blood cell count and erythrocyte count of the observation group and the control group were all reduced to normal values, hemoglobin also decreased, but still higher than the normal value, the difference was not statistically significant (P> 0.05). Conclusion Bacillus coagulans livelobe tablets treatment of breast milk jaundice can increase the total effective rate, rapidly reduce the level of bilirubin, shorten the jaundice subsided time, and no adverse reactions.