随着抗生素的广泛使用,细菌处在抗生素的选择压力下产生耐药性变异。目前,以铜绿假单胞菌为代表的多重耐药或泛耐药菌株的出现,给临床治疗带来一系列的难题。其中通过基因的水平转移,获得外源性耐药基因是临床耐药菌株产生与播散加快的重要原因。整合子通过位点特异性重组捕获外源基因盒并使之表达,同时整合子可位于质粒上,或自身作为转座子的一个组成部 With the widespread use of antibiotics, bacteria are at resistance to antibiotic selection pressure variation. At present, the emergence of multi-resistant or pan-resistant strains, represented by Pseudomonas aeruginosa, brings a series of problems for clinical treatment. Among them, the exogenous drug-resistance gene is the important reason for the emergence and spread of clinical drug-resistant strains through the horizontal transfer of genes. The integron captures and expresses the exogenous gene cassette by site-specific recombination while the integron may be on the plasmid or itself as a component of the transposon