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建立了测定体外溶出介质中甘草酸二铵（ＤＧ）及血浆中ＤＧ的反相高效液相色谱法，并对含有β－环状糊精（ＣＤ）的ＤＧ胶囊（Ａ）与不含ＣＤ的ＤＧ胶囊（Ｂ）进行了体外港出度和动物体内生物利用度的研究。体外溶出度试验表明：两种胶囊的Ｔ＿（５０）差异非常显著（Ｐ＜０．０１），胶囊Ａ主药的溶出比Ｂ快。生物利用度试验表明：胶囊Ｂ相对于Ａ的口服吸收分数为０．７７．口服胶囊后主药（ＤＧ）的体内过程符合表现一级吸收和一级消除的二室模型。
A reversed-phase high-performance liquid chromatography (HPLC) was developed for the determination of DG and DG in vitro dissolution media. DG capsules containing β-cyclodextrin (CD) DG capsules (B) were studied in vitro and in vivo animal bioavailability. In vitro dissolution test showed that: T_ (50) difference between the two capsules was very significant (P <0.01), capsule A main drug dissolution faster than B. Bioavailability tests showed that the oral absorption fraction of capsule B relative to A was 0.77. The in vivo process of the primary drug (DG) following oral administration of the capsule conforms to a two-compartment model that exhibits primary absorption and primary elimination.