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目的:基于肝郁大鼠模型的肝功能与胃肠功能变化,初步探讨“见肝之病,知肝传脾”的客观性,为未病先防,已病防传提供科学依据。方法:SD大鼠16只,雄性,体重(180±20)g,采用随机数字表法分为正常组和模型组,每组8只。采用慢性束缚应激法复制肝郁大鼠模型,观察比较两组大鼠的外观状态、体重增长情况、血清中天门冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、胃动素(MTL)、胃泌素(GAS)、生长抑素(SS)、胆囊收缩素(CCK)的含量以及尿D-木糖排泄率(UD-x ER)。结果:与正常对照组比较,模型组大鼠体重增长量降低(P<0.05);血清中ALT、AST含量升高(P<0.05),GAS、MTL、CCK含量降低(P<0.05),SS含量升高(P<0.05),尿D-木糖排泄率降低(P<0.05)。结论:肝郁证候的出现常常伴随着脾虚证候,肝脏功能的损伤与胃肠激素的变化、小肠吸收功能的下降密切相关,初步表明“见肝之病,知肝传脾”的客观性。
Objective: Based on the changes of liver function and gastrointestinal function in rats with liver-qi stagnation, we first discussed the objectivity of “see the liver disease and know the liver-transmitted spleen” to provide a scientific basis for the prevention and treatment of disease-free and disease-prevention. Methods: Sixteen SD rats, male, weighing 180 ± 20 g, were divided into normal group and model group by random number table. The model of liver depression was induced by chronic restraint stress. The appearance, body weight, serum AST, ALT, MTL, GAS, SS, CCK and urinary D-xylose excretion rate (UD-x ER). Results: Compared with the normal control group, the weight gain of rats in the model group decreased (P <0.05), the contents of ALT and AST in serum increased (P <0.05), the contents of GAS, MTL and CCK decreased (P <0.05), urinary D-xylose excretion rate decreased (P <0.05). Conclusion: Syndromes of stagnation of liver are often accompanied by spleen deficiency syndrome. The damage of liver function is closely related to the change of gut hormones and the decline of intestinal absorption function. It is initially indicated that the symptoms of liver disease and liver metastasis are obvious. objectivity.