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目的探讨MRI的白质高信号与帕金森病(Parkinson’sdisease,PD)的临床特征之间的关系。方法对90例PD患者和60例年龄匹配的健康对照者进行MRI检查,对比分析PD组和对照组中MRI的白质高信号(包括侧脑室周围和半卵圆中心的白质高信号)的发生率,并研究白质高信号和PD的病程和病情等临床特征之间的关系。结果PD组比对照组侧脑室周围白质高信号的发生率明显增高(P<0.05),并且有侧脑室周围白质高信号的PD患者比无侧脑室周围白质高信号的PD患者具有更短的病程和更严重的病情(P<0.05)。但是,PD组的半卵圆中心白质高信号的发生率与对照组无明显差异(P>0.05),并且有卵圆中心白质高信号的PD患者的病程和病情与无半卵圆中心白质高信号PD患者无明显差异(P>0.05)。结论侧脑室周围白质高信号也许是PD的一个具有更快神经变性过程的临床亚型的标志。
Objective To investigate the relationship between MRI white matter hyperplasia and clinical features of Parkinson’s disease (PD). Methods Ninety patients with PD and 60 age-matched healthy controls were examined by MRI. The incidence of white matter hyperintensities (including white matter hyperintensities around the lateral ventricle and the semi-oval center) were compared between the PD group and the control group , And to study the relationship between the white matter high signal and the clinical course of PD and other clinical features. Results The incidence of white matter hyperintensities in the PD group was significantly higher than that in the control group (P <0.05), and PD patients with high white matter in the periventricular area had a shorter duration of disease than those without PD And more serious condition (P <0.05). However, the incidence of white matter hyperintensity in the semi-oval center of the PD group was not significantly different from that of the control group (P> 0.05). The course and severity of PD patients with oval center white matter hyperintensity were similar to those without the semi-oval center white matter There was no significant difference in signal PD (P> 0.05). Conclusion Periventricular white matter hyperintensities may be a hallmark of a clinical subtype of PD with a faster neurodegeneration.