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目的观察用１９２Ｉｒ后装机对脑瘤行间质内照射的生物学反应与疗效。材料与方法选用Ｇ４２２皮下荷瘤小鼠模型作照射后肿瘤生长抑制试验及Ｃ６胶质母细胞瘤脑内荷瘤模型作照射后小鼠存活期延长试验，并进行病理学观察。各设２．５Ｇｙ，１０Ｇｙ及对照３个组进行。结果照射后１４天Ｇ４２２皮下肿瘤体积：对照组，２．５Ｇｙ组和１０Ｇｙ组分别为８．３４±１．９８ｃｍ３，５．７３±３．９３ｃｍ３和１．００±１．９ｃｍ３，３组间有显著差异。Ｃ６脑内荷瘤照射后其存活期明显延长，病理学证明照射后瘤组织发生各时相的凋亡与坏死。结论用１９２Ｉｒ行脑胶质瘤间质内照射是治疗脑深部肿瘤的一种可供选择的有效方法
Objective To observe the biological response and efficacy of interstitial irradiation after cerebral infarction with 192Ir. MATERIALS AND METHODS G422 subcutaneous tumor-bearing mice model was selected for tumor growth inhibition test and C6 glioma brain tumor model for radiation-induced survival of mice and pathological observation. Each set 2.5Gy, 10Gy and control 3 groups. Results 14 days after irradiation, G422 subcutaneous tumor volume: control group, 2.5Gy group and 10Gy group were 8.34 ± 1.98cm3, 5.73 ± 3.93cm3 and 1.00 ± 1.9cm3, 3 groups were Significant differences. C6 brain tumor after irradiation significantly prolonged survival, pathological evidence of tumor tissue after irradiation occurred in each phase of apoptosis and necrosis. Conclusion 192Ir gliomas interstitial irradiation is an effective treatment for deep brain tumors