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目的了解不同水平碘摄入量与甲状腺疾病的关系,探讨个体化补碘的依据及临床意义。方法测定甲状腺疾病组和正常对照组的甲状腺功能、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)、甲状腺彩色多普勒及尿碘,比较不同疾病组患者尿碘水平。结果甲状腺功能异常、甲状腺肿及甲状腺结节患者的尿碘中位数显著高于正常对照组(P<0.01),且随尿碘水平的增加,甲状腺功能亢进症患者的初治期延长。结论碘过量会增加甲状腺疾病的发生率,尿碘测定有助于指导个体化补碘。
Objective To understand the relationship between different levels of iodine intake and thyroid diseases and to explore the basis and clinical significance of individualized iodine supplement. Methods Thyroid function, thyroid peroxidase (TPOAb), thyroglobulin antibody (TGAb), thyroid color Doppler and urinary iodine in thyroid disease group and normal control group were measured to compare the urinary iodine levels. Results The median urinary iodine in patients with thyroid dysfunction, goiter and thyroid nodules was significantly higher than that in the normal control group (P <0.01). With the increase of urinary iodine level, the initial stage of hyperthyroidism was prolonged. Conclusion Iodine excess will increase the incidence of thyroid disease, urinary iodine determination helps to guide individual iodine.