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目的观察复方陈香胃片对大鼠胃黏膜病理形态改变的影响,探讨其对胃黏膜的保护作用。方法 80只大鼠随机分为正常对照组、模型组、复方陈香片组、达喜组和三九胃泰组,每组16只。除正常对照组外均以脱氧胆酸钠、40%酒精及吲哚美辛复合化学刺激法建立慢性胃炎模型,模型复制成功后各组分别连续给药1月,取胃组织标本,观察病理形态学改变。结果与模型组比较,复方陈香片组、三九胃泰组治疗后胃黏膜炎症反应明显减轻,炎症评分均明显下降,差异有统计学意义(P<0.01);而复方陈香片组较三九胃泰组下降更明显。结论复方陈香胃片能减轻慢性胃炎胃黏膜炎症反应,具有保护胃黏膜的作用。
Objective To observe the effect of Compound Chenxiangwei Tablets on pathological changes of gastric mucosa in rats and its protective effect on gastric mucosa. Methods Totally 80 rats were randomly divided into normal control group, model group, compound Aloe vera group, Daxi group and Sanjiuweitai group, with 16 rats in each group. Chronic gastritis model was established by combined chemical stimulation with sodium deoxycholate, 40% alcohol and indometacin, except for the normal control group. After the model was successfully replicated, each group was given continuous administration for 1 month, and the gastric tissue samples were taken to observe the pathological changes Learning to change. Results Compared with the model group, the gastric mucosal inflammatory response was significantly reduced and the inflammation scores were significantly decreased in the CClA group and the Sanjiuweitai group after treatment (P <0.01) Wei Tai group decreased more pronounced. Conclusion Compound Chen Xiangwei Tablets can relieve gastric mucosal inflammatory response in chronic gastritis and have the function of protecting gastric mucosa.