论文部分内容阅读
对比观察６０例ＳＬＥ病人血浆脂质过氧化物（ＬＰＯ）、红细胞超氧化物歧化酶（ＳＯＤ）及过氧化氢酶（ＣＡＴ）含量与ＡＮＡ、ｄｓ－ＤＮＡ、Ｓｍ和Ｕ１ＲＮＰ自身抗体的变化。活动期病人活性氧基（ＯＲ）水平增高，以致ＳＯＤ及ＣＡＴ活性下降，ＬＰＯ含量增高；非活动期ＳＯＤ及ＣＡＴ活性相对增高，ＬＰＯ含量降低，提示体内ＯＲ水平下降。抗ｄｓ－ＤＮＡ抗体滴度与红细胞ＳＯＤ、ＣＡＴ、血浆ＬＰＯ含量及疾病的严重程度密切相关。内源性ＯＲ的增加可导致Ｔ抑制细胞功能下降，Ｂ淋巴细胞异常增殖，以致体内产生多种自身抗体，诱发免疫炎症反应
The levels of plasma lipid peroxides (LPO), erythrocyte superoxide dismutase (SOD) and catalase (CAT) and the changes of autoantibodies against ANA, ds-DNA, Sm and U1RNP in 60 SLE patients were compared. During the active phase, the level of reactive oxygen species (ROS) increased, the activity of SOD and CAT decreased and the content of LPO increased. The activity of SOD and CAT increased in inactive phase and the level of LPO decreased, which suggested that OR decreased. The titer of anti-ds-DNA antibody is closely related to the level of SOD, CAT, plasma LPO and the severity of the disease. Increased endogenous OR can lead to T suppress cell function decline, abnormal proliferation of B lymphocytes, resulting in a variety of autoantibodies in vivo, induced immune inflammatory reaction