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环孢菌素A(CsA)是一种免疫抑制剂,广泛用于器官移植术后及自身免疫性疾病。凡影响其吸收、代谢、排泄的因素均可影响其血药浓度。 1、影响吸收的因素: 1.1 药物剂型、给药方法:CsA口服液的为油溶液,用前将其分散在牛奶、果汁等饮料中,病人服用的是一种乳剂。葡萄汁中的某些成分可能抑制CSA在消化道的代谢。 1.2 肝功能:肝病或肝移植患者早期胆汁缺乏,使脂溶性很强的CsA吸收减少。
Cyclosporin A (CsA) is an immunosuppressive agent widely used in post-organ transplantation and autoimmune diseases. Any factors that affect their absorption, metabolism, excretion can affect their blood concentration. 1, the factors that affect the absorption: 1.1 drug dosage forms, methods of administration: CsA oral solution for the oil solution before use, it is dispersed in milk, fruit juice and other beverages, the patient is taking an emulsion. Certain components of grape juice may inhibit the metabolism of CSA in the digestive tract. 1.2 liver function: Liver or liver transplantation in patients with early bile deficiency, so fat-soluble CsA absorption decreased.