多沙唑嗪是同哌唑嗪作用机理相似的新型选择性α_1受体抑制剂。作者对两者治疗轻、中度原发性高血压的疗效进行了随机、双盲对照研究。方法 266例受试者为未接受降压治疗,舒张压在12.64～15.83 kPa,收缩压大于21.28 kPa的原发性高血压。受试者随机分为两组,先用4周安慰剂,随后为12周治疗期,多沙唑嗪每日1次,哌唑嗪每日3次。在 Doxazosin is a new selective α_1 receptor inhibitor with similar mechanism to prazosin. The authors conducted a randomized, double-blind, controlled study of their efficacy in treating mild to moderate essential hypertension. Methods A total of 266 subjects were those who had no antihypertensive treatment, with diastolic pressure ranging from 12.64 to 15.83 kPa and systolic blood pressure greater than 21.28 kPa. Subjects were randomly assigned to two groups with placebo for 4 weeks followed by 12 weeks treatment with doxazosin once daily and prazosin 3 times daily. in