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目的探讨血清中甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原199(CA199)联合检测对消化系统恶性肿瘤的诊断价值。方法采用电化学发光法分别检测200例消化系统恶性肿瘤患者(消化系统恶性肿瘤组)和90例健康体检者(健康对照组)血清中AFP、CEA、CA125、CA199的含量,分析四项肿瘤标志物及其各项肿瘤标志物联合检测对消化系统恶性肿瘤患者的诊断效能。结果四项肿瘤标志物联合检测其敏感性在胃癌、结直肠癌、胰腺癌分别为42.0%、62.0%、82.0%,明显高于单一肿瘤标志物检测,差异有统计学意义(P<0.01),肝癌四项联检的敏感性为82.0%,与AFP单项检测比较差异无统计学意义(P>0.05)。结论除肝癌外,AFP、CEA、CA125、CA199联合检测可提高诊断的敏感性,对消化系统恶性肿瘤的早期诊断具有实用价值。
Objective To investigate the diagnostic value of serum AFP, CEA, CA125 and CA199 in the diagnosis of digestive system malignancies. Methods The levels of AFP, CEA, CA125 and CA199 in serum of 200 patients with digestive system malignant tumor (digestive system malignant tumor group) and 90 healthy subjects (healthy control group) were detected by electrochemiluminescence. Four tumor markers And their tumor markers combined detection of digestive system cancer patients with diagnostic efficacy. Results The sensitivity of combined detection of four tumor markers in gastric cancer, colorectal cancer and pancreatic cancer was 42.0%, 62.0% and 82.0% respectively, which was significantly higher than that of single tumor marker (P <0.01) The sensitivity of the four co-tests of hepatocellular carcinoma was 82.0%, which was not significantly different from the single test of AFP (P> 0.05). Conclusion In addition to liver cancer, AFP, CEA, CA125, CA199 joint detection can increase the diagnostic sensitivity, early diagnosis of digestive system malignancies have practical value.