目的 :观察国产咪唑安定用作术前药和麻醉药的临床效果及对呼吸循环的影响。方法 :随机选择胸腹部手术患者 40例 ,术前用药为国产咪唑安定 0 0 7～ 0 1mg/kg ,术前 30min肌注 ;麻醉诱导用咪唑安定 0 2 0～0 30mg/kg、芬太尼 4μg/kg和琥珀胆碱 1～ 2mg/kg静注后气管内插管 ,人工通气 ,安氟醚维持麻醉。 结果 :肌注后患者安静者 30例 ,嗜睡者 10例 ;静注后对呼吸、循环无明显影响 (P >0 .0 5 ) ,意识消失时间为 (40 5± 2 1 6 )s。用药后无不良反应。结论 :国产咪唑安定镇静、催眠和麻醉诱导安全效果良好 ,不良反应少 Objective: To observe the clinical effect of domestic midazolam used as preoperative drug and anesthetic and its influence on respiratory cycle. Methods: Thirty patients with thoracoabdominal operation were selected randomly. The patients were given midazolam 0 0 7 ~ 0 1 mg / kg preoperatively and intramuscularly 30 min before operation. The anesthesia was induced with midazolam 0 2 0 ~ 0 30 mg / kg, fentanyl 4μg / kg and succinylcholine 1 ~ 2mg / kg after intravenous intubation, artificial ventilation, enflurane to maintain anesthesia. Results: After the intramuscular injection, 30 patients were quiet and 10 patients were lethargic. No significant effect on respiration and circulation was found after intravenous injection (P> 0.05). The time of consciousness disappearance was (40 5 ± 2 1 6) s. No adverse reactions after treatment. Conclusion: Domestic midazolam sedation, hypnosis and anesthesia induced good safety effect, fewer adverse reactions