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目的探讨3种含漱液预防老年慢性阻塞性肺病(COPD)患者雾化吸入布地奈德所致口腔真菌感染的疗效。方法将150例COPD需使用布地奈德雾化吸入的患者随机分为益口组、制霉菌素组、生理盐水组,观察患者口腔及咽喉部黏膜情况并取涂片做真菌培养,观察患者对漱口液的耐受程度。结果益口组与制霉菌素组真菌涂片及口咽部不适的比较差异无统计学意义(P>0.05);两组与生理盐水组比较,差异有统计学意义(P<0.05);益口组与生理盐水组患者的口感均舒适。结论益口含漱液及制霉菌素含漱液均可有效降低老年COPD患者雾化吸入布地奈德致口腔真菌感染的发生率,益口含漱液口感更舒适。
Objective To investigate the efficacy of three gargle in preventing oral fungal infection caused by inhalation of budesonide in elderly patients with chronic obstructive pulmonary disease (COPD). Methods A total of 150 COPD patients who were treated with inhaled budesonide were randomly divided into Yikou group, nystatin group and saline group. The oral and throat mucosa of the patients were observed and the smear was taken for fungal culture. Mouthwash tolerance level. Results There was no significant difference in fungal smear and oropharyngeal discomfort between Yikou and Nystatin groups (P> 0.05). The difference between the two groups was statistically significant (P <0.05) Mouth and saline patients are comfortable. Conclusion Yikou gargle and nystatin gargle can effectively reduce the incidence of oral fungal infection induced by inhaled budesonide in elderly patients with COPD. Yikou gargle is more comfortable.