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通过观察ＳＤ大鼠肝细胞的超微结构改变，以及与血药浓度的关系，旨在研究环孢素Ａ（ＣｓＡ）所致肝脏毒性作用的机理。给药后肝细胞早期以线粒体、粗面内质网、滑面内质网、细胞核的改变为主，肝细胞及毛细胆管内胆汁瘀积，溶酶体及微体增多集中于细胞核周围；晚期为以纤维细胞及枯否细胞增生为主的恢复样改变，溶酶体及微体集中于细胞膜附近，实验结果提示：ＣｓＡ的肝毒性作用具有明显的时相效应，并与血药浓度密切相关；保肝治疗可减轻肝毒性，且易于恢复。
The aim of this study is to investigate the mechanism of hepatic toxicity induced by cyclosporin A (CsA) by observing the ultrastructural changes of hepatocytes in SD rats and its relationship with plasma concentration. After administration, the changes of mitochondria, rough endoplasmic reticulum, synovial endoplasmic reticulum and nucleus in liver cells were predominated in the hepatocytes. Cholestasis of liver cells and capillary bile ducts were observed. Lysosomes and microdialysis were mainly concentrated around the nucleus. In order to fibroblasts and Kupffer cell proliferation-like recovery-like changes, lysosomes and micro-concentrated in the vicinity of the cell membrane, the experimental results suggest that: CsA hepatotoxicity has a significant phase-response and is closely related with plasma concentration ; Liver treatment can reduce liver toxicity, and easy to recover.