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奥沙利铂(L-OHP)化学名为左旋反式二氨环己烷草酸铂,是一个稳定的水溶性的铂类烷化剂,对治疗中、晚期结直肠癌有很好的效果,市场前景十分广阔。在使用过程中,它毒性相对较低,但仍有部分患者无法耐受其所致的神经毒性、胃肠道反应及血液学毒性,个别患者可有严重过敏反应,如休克、呼吸困难、喉头水肿等,常常在使用多次后出现,这些都限制了L-OHP裸药在临床的广泛应用。而靶向药物投递系统(TDDS)被认为是解决上述问题最有效的方法之一,目前国内外已有较多此方面的相关研究。
Oxaliplatin (L-OHP) is a chemically stable, water-soluble platinum alkylating agent known as L-trans-diamino cyclohexane oxalate, which has good effect on the treatment of advanced colorectal cancer. Market prospects are very broad. In the course of its use, its toxicity is relatively low, but some patients still can not tolerate the neurotoxicity, gastrointestinal reactions and hematological toxicity. Some patients may have severe allergic reactions such as shock, dyspnea, throat Edema, etc., often appear after multiple use, which limits the wide application of L-OHP nude in clinical practice. Targeted Drug Delivery System (TDDS) is considered as one of the most effective ways to solve the above problems. At present, there are more studies in this area at home and abroad.