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观察化疗药物及高聚金葡素对癌性心包积液的治疗效果。方法 :将临床收治的癌性心包积液患者随机分为A、B两组 ,A组 2 8例 ,心包腔内注入mmc6～ 8mg ,5 -Fu5 0 0～ 75 0mg ,Dexamethason5～ 1 0mg ,高聚金葡素 2 0 0 0～ 5 0 0 0u。B组 2 2例 ,心包腔内注药同A组 ,但不加高聚金葡素。A、B两组在治疗前先抽取心包内积液 1 0 0～ 75 0ml,用药后 2h内让患者辗转身体 ,使药物在心包腔内分布均匀 ,每例用药 1～ 5次。结果 :按WHO浆膜腔积液疗效标准将疗效分为CR、PR、NC ,A组有效率 46 43% ,B组为 31 82 % ,统计学比较无显著性差异 (P>0 0 5 )。结论 :化疗及高聚金葡素对癌性心包积液有效 ,化疗加高聚金葡素的有效率高于单纯化疗组 ,但两者差异无统计学意义。
To observe the effect of chemotherapeutic drugs and polyglutamine on cancer pericardial effusion. Methods: The patients with malignant pericardial effusion admitted to our hospital were randomly divided into two groups: group A and group B, 28 cases in group A received pericardial injection of mmc6-8mg, 5-Fu500-075Omg, Dexamethason5-10mg, Polyglutamine 2 0 0 0 ~ 5 0 0 0u. Group B 2 2 cases, intrapericardial injection with the same A group, but without added polyglucamine. A and B in the two groups before treatment, pericardial effusion fluid was extracted 100 ~ 75 0ml within 2h after treatment, the patient was removed to the body, so that drugs in the pericardial distribution, each medication 1 to 5 times. Results: According to the WHO standard of serosal effusion, the curative effect was divided into CR, PR, NC, the effective rate was 46 43% in group A and 31 82% in group B, with no statistical difference (P> 0.05) . CONCLUSION: Chemotherapy and hyperinsulinemia are effective for cancerous pericardial effusion. The effective rate of chemotherapy plus hyper-AP is higher than that of chemotherapy alone, but there is no significant difference between the two groups.