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目的:探讨未分化大细胞癌的病理形态及免疫组化特点。方法:对此病例的临床病理特征进行详细的形态学观察及分析,并结合免疫组化标记及文献进行讨论。结果:此例发生部位为食道中段,瘤细胞大,圆或卵圆形,胞浆空亮,细胞呈弥散成片状,细胞质少,胞核形状不规则,深染。免疫组化:AE1/AE3(+++),EMA(++),LCA(-)。结论:食管未分化癌是少见的高度恶性肿瘤。通常分为大细胞型未化癌和小细胞型未化癌。此例为大细胞型未分化癌。
Objective: To investigate the pathological features and immunohistochemical characteristics of undifferentiated large cell carcinoma. Methods: The clinical and pathological features of this case were observed and analyzed in detail, and the immunohistochemical markers and literature were discussed. Results: The site of this case was the middle part of the esophagus. The tumor cells were large, round or oval, the cytoplasm was empty, the cells were diffuse into a sheet, the cytoplasm was less, the shape of the nucleus was irregular, and the stained cells were deeply stained. Immunohistochemistry: AE1 / AE3 (+++), EMA (++), LCA (-). Conclusion: Esophageal undifferentiated carcinoma is a rare and highly malignant tumor. Usually divided into large cell type of non-cancer and small cell type of cancer. This case is a large cell type undifferentiated carcinoma.