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探讨Pre-S2抗原在乙型肝炎病毒的各类隐性感染中的地位及科研、临床应用价值。以乙肝病毒隐性感染者作为研究对象,采用ELISA法,同时检测感染者的Pre-S2抗原和“乙肝血清标志物(HBV M)”,然后进行各类感染者之间的比较、分析。在乙肝病毒隐性感染者人群中,HBeAg阳性者、HBeAb阳性者的Pre-S2抗原阳性率分别为93．10％、60．00％;“乙肝大三阳”、“小三阳”者的Pre-S2抗原阳性率分别为92．31％、62．50％。Pre-S2抗原在判断乙肝病毒复制、隐性感染者血清的传染性强度方面,有很高使用价值和补缺作用;在判断隐性感染者的发展转化方面,亦有重大参考意义。
Pre-S2 antigen in various types of latent infection of hepatitis B virus in the status and research, clinical value. In this study, HBV infection was detected in patients with latent hepatitis B virus infection. Pre-S2 antigens and HBV M markers were also detected by ELISA, and then compared and analyzed among all the infected patients. The positive rate of Pre-S2 antigen in HBeAg-positive and HBeAb-positive patients was 93.10% and 60.00% respectively in the group of hepatitis B virus latent infection. The positive rate of Pre-S2 antigen in HBeAg-positive and HBeAb- -S2 antigen positive rates were 92.31%, 62.50%. Pre-S2 antigen in the diagnosis of hepatitis B virus replication, latent infectious serum sera of infectivity, high value and fill in the role of complement; in determining the development and transformation of latent infection, there is a significant reference value.