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目的研究特比萘芬对小鼠胚胎的致畸作用。方法将特比萘芬用２２５ｍｇ／ｋｇ、４５０ｍｇ／ｋｇ、９００ｍｇ／ｋｇ３个剂量，于小鼠妊娠第６～１５ｄ，每天经口给药１次。结果３个剂量组孕鼠体重增长、着床数、活胎数、吸收胎数、死胎数无明显改变。９００ｍｇ／ｋｇ、４５０ｍｇ／ｋｇ剂量组胎鼠体重、身长改变明显。２２５ｍｇ／ｋｇ剂量组胎鼠体重、身长无明显改变。３个剂量组胎鼠骨骼、外观和内脏均无异常发现。结论特比萘芬对小鼠无致畸作用
Objective To study the teratogenic effects of terbinafine on mouse embryos. Methods Terbinafine was administered orally once a day at doses of 225mg / kg, 450mg / kg, 900mg / kg and 6 to 15 days of gestation. Results The body weight, number of implants, numbers of live births, number of absorbed fetuses and number of stillbirth in the three dose groups did not change significantly. The body weight and body length of 900mg / kg and 450mg / kg dose groups changed obviously. 225mg / kg dose group fetal weight, length no significant change. There was no abnormality in the appearances and viscera of the three groups of fetal rats. Conclusion Terbinafine has no teratogenic effect on mice