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目的探讨微循环障碍在急性胰腺炎发病中的病理机制及杏丁注射液对改善微循环的效果。方法选择Wistar大鼠为对象,经十二指肠胆胰管逆行加压注射5%牛磺胆酸钠,建立急性胰腺炎模型,静脉输入银杏注射液。测定TXB2、PGF1的浓度,同时观察大鼠胰腺组织的病理形态学变化。结果TXB2、PGF1、T/P随病情加重总趋势上升,银杏液可改善这种趋势。结论银杏注射液可以改善微循环、减轻病情,阻止其进一步发展。
Objective To investigate the pathological mechanism of microcirculation disturbance in the pathogenesis of acute pancreatitis and the effect of Xingding injection on improving microcirculation. Methods Wistar rats were selected as the target. After the duodenal and pancreatic duct were retrogradely injected with 5% sodium taurocholate, the model of acute pancreatitis was established. The ginkgo injection was intravenously injected. The concentrations of TXB2 and PGF1 were determined, and the pathological changes of rat pancreas were observed. Results TXB2, PGF1, T / P increased with the general trend of rising disease, Ginkgo biloba can improve this trend. Conclusion Ginkgo biloba injection can improve microcirculation, reduce the disease, prevent its further development.