合成具有抗辐射活性的磷化合物是发展辐射防护剂的一个重要方面。本文综合报道几种类型磷化合物的合成方法及抗辐射活性。 1.二烷基磷酰氰酯 二乙基磷酰氰酯最早由Saunders等所合成。后来日本工作者对前人的方法曾进行过一些改变,就在这时候,作者和戴昌世提出一种新合成法,即用二烷基亚磷酸酯(5)在四氯化碳中与氰化钠在适当条件下反应,得磷酰氰酯(1)。结果满意。反应式如下: Synthesis of anti-radiation activity of phosphorus compounds is an important aspect of the development of radioprotectants. This article comprehensively reports the synthesis of several types of phosphorus compounds and anti-radiation activity. 1. Dialkyl phosphoryl cyanide diethyl phosphono cyanide was first synthesized by Saunders et al. Later, Japanese workers made some changes to their predecessors’ methods. At this time, the authors and Dai Changshi proposed a new synthesis method that uses dialkyl phosphite (5) in carbon tetrachloride and cyanide Sodium under appropriate conditions, to give phosphoryl cyanide (1). Satisfactory results. The reaction is as follows: