论文部分内容阅读
目的探讨宫颈癌介入治疗(动脉内灌注化疗)术前血清血管内皮生长因子(VEGF)检测的临床价值及对介入治疗疗效的影响。方法 35例ⅠB-ⅣA期宫颈癌介入治疗术前采用酶联免疫吸附试验(ELISA)测定血清VEGF,比较不同年龄、临床分期、肿瘤分级、病理类型、肿瘤大小、是否淋巴转移的血清VEGF水平差异,分析血清VEGF水平对介入治疗疗效及生存时间的影响;应用多因素Cox风险比例模型分析影响预后的因素。结果血清VEGF在不同肿瘤大小(P=0.001)、病理类型(P=0.026)患者中存在差异;并对介入治疗疗效(P=0.012)及生存时间存在显著影响(log rank P=0.001)。多因素分析显示,临床分期(P=0.019)、血清VEGF水平(P=0.009)、介入治疗疗效(P=0.007)是患者预后的独立影响因素。结论宫颈癌血清VEGF水平对介入治疗疗效及生存时间存在显著影响,具有重要的临床价值。
Objective To investigate the clinical value of serum vascular endothelial growth factor (VEGF) detection before interventional therapy of cervical cancer (intra-arterial infusion chemotherapy) and its effect on the therapeutic effect of interventional therapy. Methods Serum levels of VEGF were measured by enzyme-linked immunosorbent assay (ELISA) in 35 cases of ⅠB-ⅣA cervical cancer before operation. The serum VEGF levels were compared between different ages, clinical stage, tumor grade, pathological type, tumor size and lymph node metastasis . The effect of serum VEGF on the curative effect and survival time of interventional therapy was analyzed. The factors affecting the prognosis were analyzed by multivariate Cox proportional hazard model. Results Serum VEGF was significantly different in patients with different tumor size (P = 0.001) and pathological type (P = 0.026), and had significant effects on the therapeutic effect (P = 0.012) and survival time (log rank P = 0.001). Multivariate analysis showed that clinical stage (P = 0.019), serum VEGF level (P = 0.009) and interventional therapy (P = 0.007) were independent prognostic factors. Conclusion The serum level of VEGF in cervical cancer has significant effect on the curative effect and survival time of interventional therapy, which has important clinical value.