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目的:报道1例肺内骨外骨肉瘤并探讨其临床病理学特征。方法:对1例肺内骨外骨肉瘤进行临床、组织病理学及免疫组化的观察。结果:肿瘤细胞弥漫分布,细胞核深染,异型性明显。瘤组织内可见肿瘤性骨质。免疫组化示肿瘤细胞表达Vimentin及CD99,不表达MC,CR,SM-actin,Desmin,S-100,NSE,Syn,CgA,Bcl-2,CD34,CD117,HMB45,Melanoma-pan,LCA,AACT,CD68,CK,EMA,CD15及CEA。结论:肺内骨外骨肉瘤发病率低,预后差,早期发现、早期治疗有利于提高患者的生存率。本病需要与发生于肺内伴有骨化的其它肿瘤进行鉴别诊断。
Objective: To report a case of extra-osseous osteosarcoma in the lung and discuss its clinicopathological features. Methods: One case of extra-osseous osteosarcoma in the lung was observed by clinical, histopathological and immunohistochemical methods. RESULTS: The tumor cells were diffusely distributed, with deep staining of nuclei and obvious heterogeneity. Tumorous bone was found in the tumor tissue. Immunohistochemistry showed that tumor cells express Vimentin and CD99, but not MC, CR, SM-actin, Desmin, S-100, NSE, Syn, CgA, Bcl-2, CD34, CD117, HMB45, Melanoma-pan, LCA, AACT , CD68, CK, EMA, CD15 and CEA. Conclusion: The incidence of extraosseous osteosarcoma in the lung is low and the prognosis is poor. Early detection and early treatment are beneficial to improve the survival rate of patients. The disease needs to be differentially diagnosed with other tumors that occur in the lung with ossification.