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目的:探讨高敏C-反应蛋白(hs-CRP)对早期妊娠糖尿病(GDM)诊断的临床意义。方法:回顾性分析我院2008年1月至2012年1月收治入院的孕24-28周孕妇行葡萄糖筛查试验(GCT),GCT异常孕妇行糖耐量(75g OGTT)筛查,用高敏感干化学微粒增强型免疫浊度法检测GCT正常孕妇组(100例)和GCT异常孕妇组(100例)的hs-CRP水平。结果:GCT正常孕妇hs-CRP阳性率为6.0%,GCT异常孕妇组hs-CRP阳性率为51.0%,GCT正常与异常两组hs-CRP水平经秩和检验,存在显著性差异(P<0.05)。100例GCT异常孕妇根据葡萄糖耐量试验(OGTT)诊断,妊娠糖尿病(GDM)20例,葡萄糖代谢耐受不良(IGT)20例,其中GDM和IGT孕妇hs-CRP高水平浓度(>10mg/L)阳性率高于OGTT正常孕妇。GDM、IGT组和OGTT正常组hs-CRP阳性率各为55.0%(11/20)、50.0%(10/20)和50%(30/60)。结论:高敏C-反应蛋白(hs-CRP)参与了早期妊娠糖尿病(GDM)的发生发展,检测早期孕妇高敏CRP,对妊娠糖尿病的预防与控制具有十分重要的意义。
Objective: To investigate the clinical significance of high-sensitivity C-reactive protein (hs-CRP) in the diagnosis of early gestational diabetes mellitus (GDM). Methods: A retrospective analysis of our hospital from January 2008 to January 2012 admission pregnant 24-28 weeks pregnant women underwent glucose screening test (GCT), GCT abnormal glucose tolerance (75g OGTT) screening, high sensitivity The levels of hs-CRP in GCT normal pregnant women group (100 cases) and GCT abnormal pregnant women group (100 cases) were detected by dry chemical microparticle-enhanced immunoturbidimetry. Results: The positive rate of hs-CRP in normal pregnant women with GCT was 6.0%, while the positive rate of hs-CRP in pregnant women with GCT was 51.0%. The levels of hs-CRP in normal and abnormal GCT groups were significantly different (P <0.05) ). According to the results of glucose tolerance test (OGTT), 20 cases of abnormal glucose metabolism (IGT) and 20 cases of abnormal glucose metabolism (IGT) were diagnosed in 100 pregnant women with GCT. The high level of hs-CRP (> 10mg / L) The positive rate is higher than normal pregnant women with OGTT. The positive rates of hs-CRP in GDM, IGT group and normal OGTT group were 55.0% (11/20), 50.0% (10/20) and 50% (30/60) respectively. CONCLUSIONS: High-sensitivity C-reactive protein (hs-CRP) is involved in the development of early gestational diabetes mellitus (GDM). Detection of high-sensitive CRP in early pregnant women is of great significance for the prevention and control of gestational diabetes mellitus.