肾小球硬化的病理生理基础是肾小球细胞外基质(ECM)积聚 ,纤溶酶原激活物及其抑制物 (PA/PAI)是调节ECM降解的重要酶系 ,研究表明肾炎病变组织中存在PA/PAI的异常表达[1] ,但在肾炎患者血浆中的变化报道甚少。本研究测定原发性肾病综合征 (NS)患者血浆组织型纤溶酶原激活物 (tP The pathophysiology of glomerulosclerosis is the accumulation of glomerular extracellular matrix (ECM). Plasminogen activators and their inhibitors (PA / PAI) are important enzymes that regulate the degradation of ECM. Studies have shown that in nephritis lesions There is abnormal expression of PA / PAI [1], but little change has been reported in the plasma of nephritis patients. This study measured plasma neutrophil plasminogen activator (tP) in patients with primary nephrotic syndrome (NS)