论文部分内容阅读
作者检查了29例治疗方案相同持续缓解30月以上的急性淋巴细胞白血病患儿。2例在停止治疗前已临床复发,其中1例于诊断后34月发现双侧睾丸肿大,9例停止治疗后5例复发,其中4例分别于3、4和17月发现单侧睾丸肿大。作者对后4例患儿均作双侧睾丸活检,明显受累睾丸,其切面轻度肿胀、缺乏正常细粒网状结构。显微镜下发现白血病细胞均匀地浸润,正常睾丸组织消失,对侧睾丸没有白血病细胞浸润。作者以睾丸活检作为估价停止治疗的指征,并检查了18例存活34～40月的病儿,发现其外观正常者,在显微镜下有4例睾丸间质呈弥漫性浸润,2例呈局限性浸润。
The authors examined 29 children with acute lymphoblastic leukemia who had the same sustained response over 30 months as the same regimen. Two patients had been clinically relapsed before treatment was discontinued. One patient had bilateral testicular enlargement at 34 months after diagnosis and 5 patients relapsed after 9 patients stopped treatment. Four of them had unilateral testicular swelling at 3,4 and 17 months Big. The authors performed bilateral testicular biopsies on the last 4 cases of children, who were significantly affected by the testes with slight swelling of their section and lack of normal fine-grained reticular structures. Microscopic leukemia cells were found to be evenly infiltrated, normal testicular tissue disappeared, and contralateral testes without leukemic cell infiltration. The authors used testicular biopsy as an indication of cessation of treatment and examined 18 children who survived from 34 to 40 months and found that their appearance was normal under microscope with diffuse infiltration of the testicular stroma in 4 and limitations in 2 Sexual infiltration.