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观察长春瑞滨 (诺维本 ,NVB)联合顺铂 (DDP)治疗非小细胞肺癌的疗效。方法 :6 0例患者分别用NP(NVB加DDP)方案和MNP[丝裂霉素 (MMC)联合NVB与DDP]方案治疗。结果 :NP和MNP组有效率分别为42 9% (12 2 8)和 46 9% (15 32 ) ,两者无显著差异 (P >0 0 5 )。分析诸多因素对疗效的影响发现 ,病期早较病期晚疗效好 ,鳞癌比腺癌疗效好。骨髓抑制为限制性毒性 ,白细胞下降NP组为 82 1% ,MNP组为 87 5 % ,P >0 0 5 ,无其他严重毒副反应。结论 :治疗非小细胞肺癌 ,NP方案能获得与MNP方案相似的疗效 ,且白细胞下降幅度低
To observe the curative effect of vinorelbine (NVB, NVB) combined with cisplatin (DDP) on non-small cell lung cancer. Methods: Sixty patients were treated with NP (NVB plus DDP) and MNP (MMC combined with NVB and DDP) respectively. Results: The effective rates of NP and MNP were 42 9% (12 2 8) and 46 9% (15 32), respectively. There was no significant difference between the two groups (P 0 05). Analysis of the impact of many factors on the efficacy found that the disease earlier than the late efficacy of disease, squamous cell carcinoma is better than adenocarcinoma. Myelosuppression was limited toxicity, leukopenia was 82% in NP group, 87.5% in MNP group, P> 0.05, no other serious side effects. CONCLUSIONS: In the treatment of non-small cell lung cancer, the NP regimen achieves similar efficacy as the MNP regimen with a low leukopenia