中枢神经系统的疾病常常表现为痉挛性发作,如各种类型的癫癎、帕金森氏病、舞蹈型和肌阵挛型运动过度症等。某些巴比妥酸类、乙内酰脲类、噁唑烷类、丁二酰亚胺类、羧酸酯和酰胺类的抗痉挛药物已在临床中使用。本文概述关于研究和合成抗痉挛药物的情况,同时就化学结构与抗痉挛作用之间的关系作出某些结论。巴比妥酸衍生物 1938年以前,巴比妥酸类是唯一的抗痉挛药物,至今仍然被人们所重视。临床中广泛应用的巴比妥酸(酰脲丙二酸)衍生物是苯巴比妥,它具有镇静、安眠和抗痉挛作用,常用于癫痫的大发作。在巴比妥酸衍生物中研究新的抗痉挛药 Central nervous system diseases often manifest as spastic seizures, such as various types of epilepsy, Parkinson’s disease, dance and myoclonus-type hyperactivity disorders. Some anti-spastic drugs of barbiturates, hydantoins, oxazolidines, succinimides, carboxylates and amides have been used clinically. This article provides an overview of the research and synthesis of antispasmodic drugs and makes some conclusions about the relationship between chemical structure and anti-spasticity. Barbituric Acid Derivatives Until 1938, barbiturates were the only antispasmodic drug and so far they are still valued. Barbituric acid (DMF) derivatives widely used in clinic are phenobarbital, which has the functions of sedation, hypnosis and anticonvulsant and is commonly used in the seizure of epilepsy. Study new anti-spasticity drugs in barbituric acid derivatives