目的　观察甲钴胺对糖尿病周围神经病变的疗效。方法　对 40例糖尿病周围神经病变病人随机分组对照临床观察 ,治疗组 2 0例以甲钴胺 5 0 0 μg口服 ,每天 3次 ;对照组 2 0例服腺苷辅酶B12 5 0 0 μg ,每天3次。两组疗程均为 4周。结果　 4周后自觉症状改善 ,神经传导速度提高。结论　甲钴胺是治疗糖尿病周围神经病变的一种有效药物。 Objective To observe the effect of mecobalamin on diabetic peripheral neuropathy. Methods 40 cases of diabetic peripheral neuropathy patients randomized controlled clinical observation, the treatment group 20 cases with methylcobalamin 500 μg orally 3 times a day; the control group 20 cases of adenosine coenzyme B12 500 μg daily 3 times. Two courses of treatment were 4 weeks. Results 4 weeks after symptoms improved, nerve conduction velocity increased. Conclusion Mecobalamin is an effective drug for the treatment of diabetic peripheral neuropathy.