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目的探讨Ku70在卵巢浆液性肿瘤组织中的表达及临床意义。方法免疫组化方法检测20例正常卵巢、100例卵巢浆液性肿瘤(卵巢浆液性囊腺瘤30例、卵巢交界性浆液性囊腺瘤20例和卵巢浆液性囊腺癌50例)组织中Ku70的表达,分析其表达与临床病理参数之间的相关性。结果 Ku70在正常卵巢组织,良性、交界性和恶性卵巢浆液性组织中都有不同程度的表达,且在交界性和恶性卵巢浆液性组织中的表达明显高于正常卵巢组织和卵巢囊腺瘤(P<0.01),卵巢癌组织分化程度越差Ku70的阳性率越高,表达强度亦越强,与肿瘤的临床分期、腹水、淋巴结转移均相关(P<0.05)。结论 Ku70的异常表达与卵巢浆液性肿瘤恶变相关。
Objective To investigate the expression of Ku70 in ovarian serous tumors and its clinical significance. Methods Immunohistochemical method was used to detect the expression of ku70 in 20 cases of normal ovary, 100 cases of ovarian serous tumors (30 cases of ovarian serous cystadenoma, 20 cases of ovarian borderline serous cystadenoma and 50 cases of ovarian serous cystadenocarcinoma) The correlation between the expression and clinicopathological parameters was analyzed. Results Ku70 expression was different in normal ovarian tissue, benign, borderline and malignant ovarian serous tissues, and was significantly higher in borderline and malignant ovarian serous tissues than in normal ovarian tissues and ovarian cystadenomas P <0.01). The higher the positive rate of Ku70 was, the higher the expression of Ku70 protein was. The higher the expression of Ku70 protein was, the higher the clinical grade, the ascites and lymph node metastasis were (P <0.05). Conclusion The abnormal expression of Ku70 is associated with the malignant transformation of ovarian serous tumors.