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遗传因素是男性不育的主要病因之一,并可通过辅助生殖技术垂直传递给男性子代。相当数量的临床非特发性重度少精子或无精子患者有AZF缺失。与精子发生有关的基因大量集中在Y染色体长臂的AZF区。在男性不育临床有必要开展使用外周血细胞DNA的AZF检查。
Genetic factors are one of the major causes of male infertility and can be passed vertically to male offspring through assisted reproductive technology. A significant number of patients with clinically non-idiopathic severe oligospermia or azoospermia have AZF deletions. A large number of genes associated with spermatogenesis are concentrated in the AZF region of the long arm of the Y chromosome. In male infertility clinically necessary to carry out the use of peripheral blood cell DNA AZF examination.