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目的：观察重组α-干扰素治疗慢性乙型肝炎的疗效。方法：采用干扰素治疗30例慢性乙型肝炎患者。用3Mu干扰能，每日一次，两周后改为隔日一次，疗程3个月，随访1年。结果：治疗组HBeAg转阴率43．33％，对照组13．33％（P＜0．05）。治疗组HBVDNA转阴率为36．67％，对照组10％（P＜0．05）。治疗组总有效率56．67％，对照组23.33％（P＜0．01）。86．67％患者使用干扰能后出现不同程度的副作用。结论：干扰能能有效抑制慢性乙型肝炎患者的HBV复制。
Objective: To observe the effect of recombinant interferon-α on chronic hepatitis B. Methods: Interferon treatment of 30 patients with chronic hepatitis B. 3Mu interference can be used once a day, two weeks later changed to every other day, the course of 3 months, followed up for 1 year. Results: The HBeAg negative rate in the treatment group was 43.33% and that in the control group was 13.33% (P <0.05). The negative rate of HBVDNA in the treatment group was 36.67% and in the control group 10% (P <0.05). The total effective rate was 56.67% in the treatment group and 23.33% in the control group (P <0.01). There were different degrees of side effects in 86.67% of patients after interference. Conclusion: Interference can effectively inhibit HBV replication in patients with chronic hepatitis B.