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目的探讨缺氧缺血性脑病(hypoxie-ischemic encephalopathy,HIE)早产儿血清Tau蛋白水平的变化及其临床意义。方法选择邢台市人民医院新生儿科2014年1-7月间住院的早产儿HIE病例30例为实验组,同期住院的正常早产儿20例为对照组,采用酶联免疫吸附试验检测两组患儿急性期(出生后1~3 d)和恢复期(出生后7~10 d)血清Tau蛋白水平。HIE早产儿实验组按病情分为轻度、中重度两组。结果对照组出生后急性期Tau蛋白水平为(3.08±2.28)ng/ml,恢复期为(2.67±2.41)ng/ml,轻度HIE组急性期为(6.84±4.47)ng/ml,恢复期为(2.46±1.89)ng/ml,中重度HIE组急性期为(7.21±3.64)ng/ml,恢复期为(2.52±1.74)ng/ml,急性期HIE组血清Tau蛋白水平明显高于对照组(P<0.05);HIE轻度组、中重度组、对照组组间比较,差异有统计学意义(P<0.05)。其中重度HIE组的Tau蛋白水平明显高于轻度组及对照组(P<0.05)。HIE急性期Tau的水平与脑组织损伤程度呈正相关。结论 Tau水平测定可作为协助HIE临床分度、判断脑损伤程度及预测预后的指标。早期检测早产儿血清Tau蛋白含量对早产儿HIE的早期诊断及治疗有重要意义。
Objective To investigate the changes of serum Tau protein in hypoxic-ischemic encephalopathy (HIE) premature infants and its clinical significance. Methods 30 cases of HIE in hospitalized neonates admitted to Department of Neonatology, Xingtai People’s Hospital from January to July 2014 were selected as the experimental group, and 20 cases of normal premature infants in the same period as the control group. Enzyme-linked immunosorbent assay Serum Tau protein levels in acute phase (1 ~ 3 days after birth) and convalescence (7 ~ 10 days after birth). HIE preterm children experimental group according to the disease is divided into mild, moderate and severe two groups. Results In the control group, the level of Tau protein was (3.08 ± 2.28) ng / ml and the recovery time was (2.67 ± 2.41) ng / ml at the acute stage after birth. The recovery rate was (6.84 ± 4.47) ng / (2.46 ± 1.89) ng / ml. The acute phase of moderate and severe HIE group was (7.21 ± 3.64) ng / ml and the recovery period was (2.52 ± 1.74) ng / ml. The level of serum Tau protein in HIE group was significantly higher than that in control group Group (P <0.05). There was significant difference between HIE mild group, moderate and severe group and control group (P <0.05). Tau protein level in severe HIE group was significantly higher than that in mild group and control group (P <0.05). The level of Tau in acute phase of HIE was positively correlated with the degree of brain injury. Conclusion The Tau level can be used as an index for assisting HIE in clinical classification, judging the degree of brain injury and predicting the prognosis. Early detection of serum Tau protein in preterm children is of great significance in the early diagnosis and treatment of premature neonates with HIE.