Objective:To assess economic cost-effects for the screening programs of gastric cancer in a high risk population in northeastern China.Methods:The data were collected from November 2001 to December 2003.The multi-stage sampling to define the screening group and the control group was applied in this study.Two stage screening programs were used in the study.An epidemiological survey and serum PG test were carried out in the first stage.The endoscopy and pathological examination were performed in the second stage screening.Effectiveness was assessed by the increased quality adjusted life-year(QALY) because of reduced gastric cancer deaths in screening.Results:A total of 27,970 participants(n=7,128 screening group,n=20,842 control group) were enrolled in the survey.Twenty nine gastric cancer cases were detected in the screening group with 20 cases in the early stage and 9 cases in the advanced stage,respectively.Eighty six gastric cancer cases were detected in the control group,all of whom were in the advanced stage and had died before the study finished.The screening and treatment of 29 cases cost $152,227 and $5,249 per each case,respectively.The costs were $459 to gain per QALY.Conclusion:The screening program of gastric cancer used in our study is an economic and society-beneficial measure to detect gastric cancer in high risk area.The methods fit China’s present economic development level. Objective:To assess economic cost-effects for the screening programs of gastric cancer in a high risk population in northeastern China.Methods:The data were collected from November 2001 to December 2003.The multi-stage sampling to define the screening group and the control Group was applied in this study.Two stage screening programs were used in the study.An epidemiological survey and serum PG test were carried out in the first stage.The endoscopy and pathological examination were performed in the second stage screening.Effectiveness was assessed by the Increased quality adjusted life-year(QALY) because of reduced gastric cancer deaths in screening.Results:A total of 27,970 participants(n=7,128 screening group,n=20,842 control group) were enrolled in the survey.Twenty nine gastric cancer cases were Detected in the screening group with 20 cases in the early stage and 9 cases in the advanced stage,respectively.Eighty six gastric cancer cases were detected in the control group,all of whom Were in the advanced stage and had died before the study finished.The screening and treatment of 29 cases cost $152,227 and $5,249 per each case,respectively.The costs were $459 to gain per QALY.Conclusion:The screening program of gastric cancer used in our Study is an economic and society-beneficial measure to detect gastric cancer in high risk area.The methods fit China’s present economic development level.